Article I, Section 8, of the U.S. Constitution

"Article I, Section 8, of the Constitution, of course, lays out the delegated, enumerated, and therefore limited powers of Congress. Only through a deliberate misreading of the general welfare and commerce clauses of the Constitution has the federal government been allowed to overreach its authority and extend its tendrils into every corner of civil society." -- Edward H. Crane, Founder and president of the Cato Institute.    Source: A Constitution of Liberty, Cato Institute 1995 Annual Report

This quote reflects the mental flaw/myth of believing specific systems and structures of American life are independent of one another.  In realty every aspect of commerce and the general welfare of ‘we the people” have an impact on “Every corner” of every aspect of our society and ultimately, the world.   Harmful elements emerging from either can threaten both the freedoms and security of the entire world.  Consider the risks fueled by antibiotic resistance exacerbated by unregulated cross border sales/distribution mixed with pockets of poverty, ignorance and/or violence.